Mariners left-hander James Paxton left Seattle's Tuesday game against the visiting Chicago White Sox in the second inning with discomfort in his left elbow, the team announced.
Paxton, making his season debut, retired the side in order in the first inning.
He walked Yoan Moncada leading off the second before a wild pitch advanced the runner to second. Yermin Mercedes then grounded out to first base.
Paxton had a 1-2 count on Andrew Vaughn when the pitcher grimaced after throwing his 24th pitch of the night and walked off the mound after a short chat with a trainer.
Paxton was replaced by left-hander Nick Margevicius.
Paxton, 32, returned to the Mariners on a one-year, $8.5 million contract this year after spending two seasons with the New York Yankees. Before that, the native of Ladner, British Columbia, played for Seattle from 2013-18.
--Field Level Media